Plasma & subcutaneous tissue pharmacokinetics of piperacillin in a large cohort of critically ill patients with sepsis

• Main Authors: Abdul Aziz, Mohd. Hafiz, Udy, Andrew A., Wallis, Steven C., Roberts, Michael S., Lipman, Jeffrey, Roberts, Jason A.
• Format: Conference or Workshop Item
• Language: English; English
• Published: 2014
• Subjects: RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/37925/2/912199_ECCMID2014_LR24.pdf; http://irep.iium.edu.my/37925/7/ECCMID_PACE_Poster_Finalv2.pdf; http://irep.iium.edu.my/37925/; http://2014.eccmid.org/

Critically ill patients with sepsis can develop profound pathophysiological changes that may alter antibiotic pharmacokinetics (PK) and produce sub-therapeutic concentrations at the sites of infection leading to therapeutic failure. We aimed to describe the plasma PK of piperacillin and its associat...