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Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA)and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis.Inhibition of PP2A activity and a...

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Bibliographic Details
Main Authors: Caillaud, A, de la Iglesia, P, Campa` s, M, Elandaloussi, L, Ferna´ndez, M, Mohammad Noor, Normawaty, Andree, K, Dioge`ne, J
Format: Article
Language:English
Published: Elsevier 2010
Subjects:
QD Chemistry
SH Aquaculture. Fisheries. Angling
Online Access:http://irep.iium.edu.my/2638/1/P-rhathymum_-Toxicon.pdf
http://irep.iium.edu.my/2638/
http://www.elsevier.com/locate/toxicon
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Summary:Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA)and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis.Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.

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