Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia

• Main Authors: Caillaud, A, de la Iglesia, P, Campa` s, M, Elandaloussi, L, Ferna´ndez, M, Mohammad Noor, Normawaty, Andree, K, Dioge`ne, J
• Format: Article
• Language: English
• Published: Elsevier 2010
• Subjects: QD Chemistry; SH Aquaculture. Fisheries. Angling
• Online Access: http://irep.iium.edu.my/2638/1/P-rhathymum_-Toxicon.pdf; http://irep.iium.edu.my/2638/; http://www.elsevier.com/locate/toxicon

Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA)and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis.Inhibition of PP2A activity and a...