Development of volumetric absorptive microsampling for analysis phenytoin levels and its application to monitoring therapy in epilepsy patients

• Main Authors: Mardhiani, Rizka, Harahap, Yahdiana, Wiratman, Winnugroho, Jaswir, Irwandi
• Format: Article
• Language: English; English
• Published: Open Science Publishers LLP 2023
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/109697/7/109697_Development%20of%20volumetric%20absorptive%20microsampling%20for%20analysis%20phenytoin.pdf; http://irep.iium.edu.my/109697/8/109697_Development%20of%20volumetric%20absorptive%20microsampling%20for%20analysis%20phenytoin_Scopus.pdf; http://irep.iium.edu.my/109697/; https://japsonline.com/abstract.php?article_id=4068&sts=2; http://dx.doi.org/10.7324/JAPS.2023.125948

Phenytoin (PHT) is an anticonvulsant drug used as monotherapy or combination therapy to treat seizures. However, PHT has a narrow therapeutic index range of 10–20 μg/ml, so it is necessary to monitor drug levels. This study aims to obtain optimum sample preparation conditions and a validated analyti...