Quantification of Dynamic 11C-Phenytoin PET Studies

• Main Authors: Mansor, Mohd Syahir, Boellaard, Ronald, Froklage, Femke E., Bakker, Esther D.M., Yaqub, Maqsood, Voskuyl, Rob A., Schwarte, Lothar A., Verbeek, Joost, Windhorst, Albert D., Lammertsma, Adriaan
• Format: Article
• Language: English
• Published: Society of Nuclear Medicine 2015
• Subjects: RM300-666 Drugs and their actions
• Online Access: http://eprints.usm.my/37523/1/syahirnuclmedpostprint.pdf; http://eprints.usm.my/37523/; http://jnm.snmjournals.org/content/56/9/1372.short

The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, 11C-phenytoin has been evaluated preclinically as a tracer for Pgp. The aim of the present study was to assess the optimal plasma kinetic model for quantification of 11...