In silico homology modelling and identification of Tousled-like kinase 1 inhibitors for glioblastoma therapy via high throughput virtual screening protein-ligand docking

• Main Authors: Kamariah Ibrahim,, Abubakar Danjuma Abdullahi,, Nor Azian Abdul Murad,, Roslan Harun,, Rahman Jamal,
• Format: Article
• Language: English
• Published: Pusat Perubatan Universiti Kebangsaan Malaysia 2018
• Online Access: http://journalarticle.ukm.my/13245/1/38-134-1-PB.pdf; http://journalarticle.ukm.my/13245/; http://spaj.ukm.my/apjmm/index.php/apjmm/issue/view/18

Glioblastoma multiforme (GBM) is a high-grade brain tumor of which the survival patients remain poor. Tousled-like kinase 1 (TLK1), a serine-threonine kinase, was identified to be overexpressed in cancers such as GBM. TLK1 plays an important role in controlling survival pathways. To date, there is n...