Overcoming the challenge of transduction of human T-cells with chimeric antigen receptor (CAR) specific for ERBB2 antigen

• Main Authors: Rusheni Munisvaradass,, Lee, Shirley Ding Suet, Koh, Avin Ee Hwan, Suresh Kumar,, Lim, Moon Nian, Shalini Vellasamy,, Syahril Abdullah,, Alarfaj, Abdullah A., Ling, Mok Pooi
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2017
• Online Access: http://journalarticle.ukm.my/11542/1/21%20Rusheni%20Munisvaradass.pdf; http://journalarticle.ukm.my/11542/; http://www.ukm.my/jsm/english_journals/vol46num10_2017/contentsVol46num10_2017.html

Breast cancer is one of the most common malignancies among woman. Decades of scientific study have linked the overexpression of ERBB2 antigen to aggressive tumors. To target aggressive breast cancer, chimeric antigen receptor (CAR) technology can be utilized. For this, human T-cells are transduced w...