Human CD3+ T-cells with the anti-ERBB2 chimeric antigen receptor exhibit efficient targeting and induce apoptosis in ERBB2 overexpressing breast cancer cells

• Main Authors: Munisvaradass, Rusheni, Subbiah, Suresh Kumar, Govindasamy, Chandramohan, Alnumair, Khalid S., Mok, Pooi Ling
• Format: Article
• Language: English
• Published: MDPI AG 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/15069/1/15069.pdf; http://psasir.upm.edu.my/id/eprint/15069/; https://www.mdpi.com/1422-0067/18/9/1797

Breast cancer is a common malignancy among women. The innate and adaptive immune responses failed to be activated owing to immune modulation in the tumour microenvironment. Decades of scientific study links the overexpression of human epidermal growth factor receptor 2 (ERBB2) antigen with aggressiv...