Synthesis, Isolation, Identification and Characterization of a Drug-Excipient Interaction Degradation Impurity in Pramipexole by HPLC, LC/MS and NMR

A drug-excipient interaction impurity associated with the degradation process of pramipexole was isolated. The impurity was detected during the stability study of pramipexole extended-release tablets. It was found at a relative retention time of 0.88 with respect to pramipexole, using the pramipexol...

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Bibliographic Details
Main Authors: Al-Rifai, N., Alshishani, A., Saad, B., Rasras, A., Zahra, J., Madieh, S., Darras, F.
Format: Article
Published: 2023
Online Access:http://scholars.utp.edu.my/id/eprint/34342/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146763954&doi=10.3390%2fseparations10010007&partnerID=40&md5=4c68c7807a2c5a7a08f2e0776a7a8d8c
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