Valuation system connectivity is correlated with poly-drug use in young adults

• Main Authors: Loganathan, K., Lv, J., Cropley, V., Zalesky, A., Ho, E.T.W.
• Format: Article
• Published: Elsevier Ireland Ltd 2021
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109778725&doi=10.1016%2fj.neures.2021.06.006&partnerID=40&md5=e0fa4b716e6e89292c36f2cf2345b246; http://eprints.utp.edu.my/29671/

Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and valuation-control complex (VCC) in a large population sample (n = 992) with drug use behaviour. VS connectivity is correlated with sedative use, ECS connectivity is separately correlated with hallucinogens and opiates. Network connectivity is also correlated with drug use via two-way interactions with other substances including alcohol and tobacco. These preliminary findings can contribute to our understanding of the common combinations of substance co-use and associated neural patterns. © 2021 Elsevier B.V. and Japan Neuroscience Society