Valuation system connectivity is correlated with poly-drug use in young adults
Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and...
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| Main Authors: | , , , , |
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| Format: | Article |
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Elsevier Ireland Ltd
2021
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109778725&doi=10.1016%2fj.neures.2021.06.006&partnerID=40&md5=e0fa4b716e6e89292c36f2cf2345b246 http://eprints.utp.edu.my/29671/ |
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| Summary: | Poly-drug consumption contributes to fatal overdose in more than half of all poly-drug users. Analyzing decision-making networks may give insight into the motivations behind poly-drug use. We correlated average functional connectivity of the valuation system (VS), executive control system (ECS) and valuation-control complex (VCC) in a large population sample (n = 992) with drug use behaviour. VS connectivity is correlated with sedative use, ECS connectivity is separately correlated with hallucinogens and opiates. Network connectivity is also correlated with drug use via two-way interactions with other substances including alcohol and tobacco. These preliminary findings can contribute to our understanding of the common combinations of substance co-use and associated neural patterns. © 2021 Elsevier B.V. and Japan Neuroscience Society |
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