Recent update on the anti-infective potential of carboline analogs

• Main Authors: Faheem, F., Kumar, B. K., Sekhar, K. V. G. C., Kun-Jiappan, S., Jamalis, J., Rafael, B. F., Sankaranarayanan, M.
• Format: Article
• Published: Bentham Science Publishers 2021
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/96513/; http://dx.doi.org/10.2174/1389557520666201001130114

β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacte-rial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and anti-thrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishma-nial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.