Recent update on the anti-infective potential of carboline analogs
β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacte-rial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and anti-thrombot...
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| Main Authors: | , , , , , , |
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| Format: | Article |
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Bentham Science Publishers
2021
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/96513/ http://dx.doi.org/10.2174/1389557520666201001130114 |
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| Summary: | β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacte-rial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and anti-thrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishma-nial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added. |
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