Biosynthesis, characterization and antiproliferative activity of green synthesized gold nanoparticles using Lantadene A extracted from Lantana camara

• Main Authors: Dawood, Dawood Ali Salim, Chua, Lee Suan, Tan, Tian Swee, Alshemary, Ahmed F.
• Format: Article
• Language: English
• Published: University of Kerbala 2021
• Subjects: Q Science (General); TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/95715/1/ChuaLeeSuan2021_BiosynthesisCharacterizationandAntiproliferativeActivity.pdf; http://eprints.utm.my/id/eprint/95715/; http://dx.doi.org/10.33640/2405-609X.3158

This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta potential (-30.11±0.83 mV). LAAuNPs showed a dose dependent cytotoxic activity with IC50, 126.82 μg/ mL against LNCaP, but non-cytotoxic to normal prostate cells. The intrinsic pathway of apoptosis was caused by the increase of caspases-3/7 and -9 activity and cell cycle arrest at the G0/G1 phase. Therefore, LA-AuNPs could be a potent lead to inhibit LNCaP.