Biosynthesis, characterization and antiproliferative activity of green synthesized gold nanoparticles using Lantadene A extracted from Lantana camara
This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta pote...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Kerbala
2021
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/95715/1/ChuaLeeSuan2021_BiosynthesisCharacterizationandAntiproliferativeActivity.pdf http://eprints.utm.my/id/eprint/95715/ http://dx.doi.org/10.33640/2405-609X.3158 |
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| Summary: | This study was focused on the biosynthesis of gold nanoparticles loaded with lantadene A (LA-AuNPs) from Lantana camara extract and the antiproliferative effects on prostate cancer cells (LNCaP). The synthesized LA-AuNPs had smooth surface, and nearly spherical in shape (67.94 nm) with the zeta potential (-30.11±0.83 mV). LAAuNPs showed a dose dependent cytotoxic activity with IC50, 126.82 μg/ mL against LNCaP, but non-cytotoxic to normal prostate cells. The intrinsic pathway of apoptosis was caused by the increase of caspases-3/7 and -9 activity and cell cycle arrest at the G0/G1 phase. Therefore, LA-AuNPs could be a potent lead to inhibit LNCaP. |
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