5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal...
Saved in:
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier Ltd.
2021
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/94936/1/MostafaYusefi2021_5-FluorouracilLoadedMagneticCellulose.pdf http://eprints.utm.my/id/eprint/94936/ http://dx.doi.org/10.1016/j.carbpol.2021.118523 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.94936 |
---|---|
record_format |
eprints |
spelling |
my.utm.949362022-04-29T21:55:09Z http://eprints.utm.my/id/eprint/94936/ 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment Yusefi, M. Kiun, M. S. L. Shameli, K. Teow, S. Y. Ali, R. R. Siew, K. K. Chan, H. Y. Wong, M. M. T. Lim, W. L. TP Chemical technology Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments. Elsevier Ltd. 2021 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/94936/1/MostafaYusefi2021_5-FluorouracilLoadedMagneticCellulose.pdf Yusefi, M. and Kiun, M. S. L. and Shameli, K. and Teow, S. Y. and Ali, R. R. and Siew, K. K. and Chan, H. Y. and Wong, M. M. T. and Lim, W. L. (2021) 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment. Carbohydrate Polymers, 273 . ISSN 0144-8617 http://dx.doi.org/10.1016/j.carbpol.2021.118523 DOI: 10.1016/j.carbpol.2021.118523 |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
language |
English |
topic |
TP Chemical technology |
spellingShingle |
TP Chemical technology Yusefi, M. Kiun, M. S. L. Shameli, K. Teow, S. Y. Ali, R. R. Siew, K. K. Chan, H. Y. Wong, M. M. T. Lim, W. L. 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
description |
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments. |
format |
Article |
author |
Yusefi, M. Kiun, M. S. L. Shameli, K. Teow, S. Y. Ali, R. R. Siew, K. K. Chan, H. Y. Wong, M. M. T. Lim, W. L. |
author_facet |
Yusefi, M. Kiun, M. S. L. Shameli, K. Teow, S. Y. Ali, R. R. Siew, K. K. Chan, H. Y. Wong, M. M. T. Lim, W. L. |
author_sort |
Yusefi, M. |
title |
5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
title_short |
5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
title_full |
5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
title_fullStr |
5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
title_full_unstemmed |
5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
title_sort |
5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment |
publisher |
Elsevier Ltd. |
publishDate |
2021 |
url |
http://eprints.utm.my/id/eprint/94936/1/MostafaYusefi2021_5-FluorouracilLoadedMagneticCellulose.pdf http://eprints.utm.my/id/eprint/94936/ http://dx.doi.org/10.1016/j.carbpol.2021.118523 |
_version_ |
1732945412166254592 |
score |
13.18916 |