5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal...
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Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier Ltd.
2021
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Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/94936/1/MostafaYusefi2021_5-FluorouracilLoadedMagneticCellulose.pdf http://eprints.utm.my/id/eprint/94936/ http://dx.doi.org/10.1016/j.carbpol.2021.118523 |
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Summary: | Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments. |
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