Synthesis, molecular docking, and antimalarial activity of hybrid 4-aminoquinoline-pyrano[2,3-c]pyrazole derivatives

• Main Authors: Shamsuddin, Mohd. Asyraf, Ali, Amatul Hamizah, Zakaria, Nur Hanis, Mohammat, Mohd. Fazli, Hamzah, Ahmad Sazali, Shaameri, Zurina, Lam, Kok Wai, Lee, Mark Wun Fui, Agustar, Hani Kartini, Mohd. Abd. Razak, Mohd. Ridzuan, Latip, Jalifah, Hassan, Nurul Izzaty
• Format: Article
• Language: English
• Published: MDPI 2021
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/94836/1/LeeWunFui2021_SynthesisMolecularDockingandAntimalarial.pdf; http://eprints.utm.my/id/eprint/94836/; http://dx.doi.org/10.3390/ph14111174

Widespread resistance of Plasmodium falciparum to current artemisinin-based combination therapies necessitate the discovery of new medicines. Pharmacophoric hybridization has become an alternative for drug resistance that lowers the risk of drug–drug adverse interactions. In this study, we synthesiz...