Molecular docking studies of phytochemicals from piper species as potential dual inhibitor of group X secreted phospholipase A2 (SPLA2-X) and Cyclooxygenase-2 (COX-2)

• Main Authors: Nadri, Muhammad Helmi, Wan Salleh, Wan Mohd. Nuzul Hakimi
• Format: Article
• Published: Diva Enterprises Pvt. Ltd. 2020
• Subjects: Q Science (General); S Agriculture (General); T Technology (General)
• Online Access: http://eprints.utm.my/id/eprint/92422/; http://dx.doi.org/10.5958/0974-360X.2020.00392.3

The group X secreted phospholipase A2 (sPLA2-X) and cyclooxygenase-2 (COX-2) are enzymes involved in biosynthesis of prostaglandins, a potent mediator of inflammation. The sPLA2-X hydrolysed membrane phospholipids to arachidonic acid and further converted into prostaglandins by COX-2. Previous studi...