New quinoxalinone inhibitors targeting secreted phospholipase A2 and alpha-glucosidase

• Main Authors: Alasmary, Fatmah A.S., Alnahdi, Fatima S., Ben Bacha, Abir G., El-Araby, Amr M., Moubayed, Nadine Ms, Alafeefy, Ahmed Mahmoud, El-Araby, Moustafa E.
• Format: Article
• Language: English; English
• Published: Informa Healthcare 2017
• Subjects: Q Science (General); QD Chemistry; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/62986/2/62986_New%20quinoxalinone%20inhibitors%20targeting%20secreted_scopus.pdf; http://irep.iium.edu.my/62986/13/62986_New%20quinoxalinone%20inhibitors.pdf; http://irep.iium.edu.my/62986/; https://www.tandfonline.com/doi/full/10.1080/14756366.2017.1363743?scroll=top&needAccess=true

Elevated blood glucose and increased activities of secreted phospholipase A2 (sPLA2) are strongly linked to coronary heart disease. In this report, our goal was to develop small heterocyclic compound that inhibit sPLA2. The title compounds were also tested against α-glucosidase and α-amylase. This a...