Synthesis and antimicrobial activity evaluation of some new 7-substituted quinolin-8-ol derivatives: POM analyses, docking, and identification of antibacterial pharmacophore sites

• Main Authors: Mohamed El Faydy, Mohamed El Faydy, Dahaieh, Naoufal, Ounine, Khadija, Rastija, Vesna, Almalki, Faisal, Jamalis, Joazaizulfazli, Zarrouk, Abdelkader, Hadda, Taïbi Ben, Lakhrissi, Brahim
• Format: Article
• Language: English
• Published: Elsevier B.V. 2021
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/90110/1/JoazaizulfazliJamalis2021_SynthesisandAntimicrobialActivityEvaluation.pdf; http://eprints.utm.my/id/eprint/90110/; http://dx.doi.org/10.1016/j.cdc.2020.100593

Eight new 7-substituted quinolin-8-ol derivatives were synthesized in moderate to good yields through quinolin-8-ol, and secondary amines as the starting reagents. The structures of the prepared compounds have been characterized by elemental analysis and 1H/13C NMR. The antimicrobial activity of thi...