Thiazole-pyrazoline hybrids as potential antimicrobial agent: Synthesis, biological evaluation, molecular docking, DFT studies and POM analysis.

• Main Authors: Salih, Rezan Huseen Hama, Hasan, Aso Hameed, Hussen, Narmin Hamaamin, Hawaiz, Farouq Emam, Hadda, Taibi Ben, Jamalis, Joazaizulfazli, Almalki, Faisal A., Adeyinka, Adedapo S., Coetzee, Louis-Charl C., Oyebamiji, Abel Kolawole
• Format: Article
• Published: Elsevier B.V. 2023
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/106957/; http://dx.doi.org/10.1016/j.molstruc.2023.135191

In this study, an efficient synthesis of new thiazole-pyrazoline hybrids was investigated and hybrids were screened for their antimicrobial activities against four species of pathogenic bacteria and one fungal strain utilizing the well-diffusion and MIC assays using ciprofloxacin and fluconazole as...