Isolation, purification, and characterization of heparinase from Streptomyces variabilis MTCC 12266

• Main Authors: Singh, Vineeta, Haque, Shafiul, Kumari, Vibha, El Enshasy, Hesham A., Mishra, B. N., Somvanshi, Pallavi, Tripathi, C. K. M.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2019
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/87847/1/HeshamAElEnshasy2019_IsolationPurificationandCharacterizationofHeparinase.pdf; http://eprints.utm.my/id/eprint/87847/; http://dx.doi.org/10.1038/s41598-019-42740-7

Arterial/venous thrombosis is the major cardiovascular disorder accountable for substantial mortality; and the current demand for antithrombotic agents is extensive. Heparinases depolymerize unfractionated heparin (UFH) for the production of low molecular-weight heparins (LMWHs; used as anticoagulan...