Preparation and evaluation of the ZnO NP-Ampicillin/Sulbactam nanoantibiotic: Optimization of formulation variables using RSM coupled GA method and antibacterial activities

• Main Authors: Sharma, Nidhi, Singh, Vineeta, Pandey, Asheesh Kumar, Mishra, Bhartendu Nath, Kulsoom, Maria, Dasgupta, Nandita, Khan, Saif, El-Enshasy, Hesham A., Haque, Shafiul
• Format: Article
• Language: English
• Published: MDPI AG 2019
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/88620/1/HeshamAliMetwally2019_PreparationandEvaluationoftheZnONP-AmpicillinSulbactamNanoantibiotic.pdf; http://eprints.utm.my/id/eprint/88620/; http://dx.doi.org/10.3390/biom9120764

Nanoparticles (NPs) possessing antibacterial activity represent an effective way of overcoming bacterial resistance. In the present work, we report a novel formulation of a nanoantibiotic formed using Ampicillin/sulbactam (Ams) and a zinc oxide nanoparticle (ZnO NP). ‘ZnO NP–Ams’ nanoantibiotic form...