Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring
In the current research, based on the investigation of the drug-loaded hydrogels, the maximum content of acyclovir loading in polymer consequently relates to the pH at which the nanoprecipitation is performed: 24.32% at pH 7.5. The efficiency of loading that corresponds to the percentage of acyclovi...
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my.utm.840902019-12-16T01:53:37Z http://eprints.utm.my/id/eprint/84090/ Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring Sabbagh, Farzaneh Muhamad, Ida Idayu Nazari, Zahra Mobini, Peyman Mahmoudi Khatir, Nadia TP Chemical technology In the current research, based on the investigation of the drug-loaded hydrogels, the maximum content of acyclovir loading in polymer consequently relates to the pH at which the nanoprecipitation is performed: 24.32% at pH 7.5. The efficiency of loading that corresponds to the percentage of acyclovir encapsulated into the vehicle for a given amount of acyclovir used is 79.97%. The drug-loaded hydrogels with 6.4% w/w, had the highest hardness with 4.1 ± 0.6 N/m2 prior and 5.6 ± 0.3 N/m2 after immersion in the SVF. Based on the FESEM images, the permeability of nano-composite hydrogels is increased. In PZC characterization, pHPZC of the acrylamide-based hydrogel in water is 4.5 that for drug-loaded hydrogel is increased to 4.7. Increasing wt% of acrylamide in the hydrogel results in yield% and gel% increasing. Increasing cross-linker concentration results in yield% or gel% increasing. Above 0.25 wt% initiator, increasing the concentration of initiator results in yield% or gel% decrease. From the MTT assay method, Acrylamide-based hydrogel demonstrated a cytotoxic effect at 12.5, 25, 50, 100 and 200 mg/mL concentrations under the condition of this study. To reduce the cytotoxic effect of these polymers, the amount of acrylamide can be decreased from 1 g to 0.5 g. Elsevier Ltd. 2018 Article PeerReviewed Sabbagh, Farzaneh and Muhamad, Ida Idayu and Nazari, Zahra and Mobini, Peyman and Mahmoudi Khatir, Nadia (2018) Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring. Materials Today Communications, 16 . pp. 274-280. ISSN 2352-4928 https://doi.org/10.1016/j.mtcomm.2018.06.010 |
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TP Chemical technology Sabbagh, Farzaneh Muhamad, Ida Idayu Nazari, Zahra Mobini, Peyman Mahmoudi Khatir, Nadia Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring |
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In the current research, based on the investigation of the drug-loaded hydrogels, the maximum content of acyclovir loading in polymer consequently relates to the pH at which the nanoprecipitation is performed: 24.32% at pH 7.5. The efficiency of loading that corresponds to the percentage of acyclovir encapsulated into the vehicle for a given amount of acyclovir used is 79.97%. The drug-loaded hydrogels with 6.4% w/w, had the highest hardness with 4.1 ± 0.6 N/m2 prior and 5.6 ± 0.3 N/m2 after immersion in the SVF. Based on the FESEM images, the permeability of nano-composite hydrogels is increased. In PZC characterization, pHPZC of the acrylamide-based hydrogel in water is 4.5 that for drug-loaded hydrogel is increased to 4.7. Increasing wt% of acrylamide in the hydrogel results in yield% and gel% increasing. Increasing cross-linker concentration results in yield% or gel% increasing. Above 0.25 wt% initiator, increasing the concentration of initiator results in yield% or gel% decrease. From the MTT assay method, Acrylamide-based hydrogel demonstrated a cytotoxic effect at 12.5, 25, 50, 100 and 200 mg/mL concentrations under the condition of this study. To reduce the cytotoxic effect of these polymers, the amount of acrylamide can be decreased from 1 g to 0.5 g. |
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Article |
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Sabbagh, Farzaneh Muhamad, Ida Idayu Nazari, Zahra Mobini, Peyman Mahmoudi Khatir, Nadia |
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Sabbagh, Farzaneh Muhamad, Ida Idayu Nazari, Zahra Mobini, Peyman Mahmoudi Khatir, Nadia |
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Sabbagh, Farzaneh |
title |
Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring |
title_short |
Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring |
title_full |
Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring |
title_fullStr |
Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring |
title_full_unstemmed |
Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring |
title_sort |
investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring |
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Elsevier Ltd. |
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2018 |
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http://eprints.utm.my/id/eprint/84090/ https://doi.org/10.1016/j.mtcomm.2018.06.010 |
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