Molecular dynamic simulation studies of three novel Gerstmann - Straussler - Scheinker and Creutzfeldt - Jacob Prion mutations

• Main Author: Jomah, Ashraf Fadhil
• Format: Thesis
• Language: English
• Published: 2016
• Subjects: QH Natural history
• Online Access: http://eprints.utm.my/id/eprint/77851/1/AshrafFadhilJomahPFBME2016.pdf; http://eprints.utm.my/id/eprint/77851/; http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:95759

The transformation of normal prion protein into pathogenic variant in transmissible spongiform encephalopathy (TSE) is expedited by mutations. Three novel mutations V176G, E196A and I215V are associated with Creutzfeldt-Jakob disease (CJD) and Gerstmann–Sträussler–Scheinker syndrome (GSS). These mut...