Molecular dynamics simulation studies of novel Q212H, V203G, and N173K mutations in prion diseases

• Main Authors: Amidian, Sara, Mohammad Riazi, Mohammad Riazi, Shahir, Mohd. Shamsir, Wille, Holger
• Format: Article
• Published: Taylor & Francis 2015
• Subjects: QC Physics
• Online Access: http://eprints.utm.my/id/eprint/58594/; https://www.tandfonline.com/doi/full/10.1080/19336896.2015.1033248

Prion diseases in humans are grouped based on whether they are sporadic, inherited, or acquired. In inherited prion disease, abnormal prion proteins (PrP) are produced through a genetic mutation of which 40 point mutations have been discovered. Three novel mutations V203G, Q212H and N173K have been...