Evaluation of pharmaceutical cream production debottlenecking schemes

• Main Authors: Tan, Jully, Foo, Dominic Chwan Yee, Kumaresan, Sivakumar, Abdul Aziz, Ramlan
• Format: Conference or Workshop Item
• Language: English
• Published: 2005
• Subjects: T Technology (General)
• Online Access: http://eprints.utm.my/id/eprint/5366/1/JullyTan2005_EvaluationOfPharmaceuticalCreamProduction.pdf; http://eprints.utm.my/id/eprint/5366/

The main objective of this work is to model and debottleneck a pharmaceutical production of an anti-allergic cream. The base case process has a minimum cycle time of 29 hours which is equivalent to 66 batches/year. Four schemes were proposed for process debottlenecking due to the anticipated increase of the product demand of 150% in the market. By carrying out throughput analysis study, schemes that fulfil the debottlenecking objective were determined. Out of the four debottlenecking schemes, Scheme 4 was chosen, which proposed a new blending tank and intermediate tank, showed a production increase of over 150%.