Antimicrobial and anti-inflammatory activities of Piper porphyrophyllum (Fam. Piperaceae)

• Main Authors: Ahmad, Farediah, Emrizal, Emrizal, M.Sirat, Hasnah, Jamaludin, Fadzureena, Mustapha, Nik Musa’adah, M.Ali, Rasadah, Arbain, Dayar, Aboul-Enein, Hassan Y.
• Format: Article
• Language: English
• Published: Elsevier B.V. 2014
• Subjects: Q Science
• Online Access: http://eprints.utm.my/id/eprint/51873/1/FarediahAhmad2014_AntimicrobialAndAnti-inflammatory.pdf; http://eprints.utm.my/id/eprint/51873/; https://doi.org/10.1016/j.arabjc.2010.12.032

The crude extracts and isolated compounds of Piper porphyrophyllum (Piperaceae) were evaluated for antibacterial and anti-inflammatory activities. The ethyl acetate extract and 3′,4′,5,7-tetramethoxyflavone exhibited the highest activity against Staphylococcus aureus giving values of MIC = 62.5 and 250 μg/mL, respectively. 5-Hydroxy-7-methoxyflavanone and 4′,5-dihydroxy-3′,7-dimethoxyflavone were active against Pseudomonas aeruginosa, both with MIC value 125 μg/mL. The hexane extract and 4′,5-dihydroxy-3′,7-dimethoxyflavone gave the highest anti-inflammatory activity in in vitro quantitative lipoxygenase inhibition assay with inhibitory activity of (IE) 99.72% and 91.81%, respectively.