Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review
Amitrityline and its metabolite nortriptiline are tricyclic antidepressant drugs widely used for the treatment of several psychiatric disorders. Several methods have been published for the determination of these two antidepressant drugs in pharmaceuticals, biological materials and environmental samp...
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my.utm.494102018-10-31T12:39:02Z http://eprints.utm.my/id/eprint/49410/ Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review Khatoon, Asma Mohd. Setapar, Siti Hamidah Ahmad, Akil Lee, Nian Yian QD Chemistry Amitrityline and its metabolite nortriptiline are tricyclic antidepressant drugs widely used for the treatment of several psychiatric disorders. Several methods have been published for the determination of these two antidepressant drugs in pharmaceuticals, biological materials and environmental samples. In this review some of analytical techniques such as ultraviolet/visible spectrophotometry, fluorimetry, capillary electrophoresis, and chromatographic methods (gaschromatography and high-performance liquid chromatography) were discussed. Although HPLC and capillary electrophoresis methods are extensively employed in spite of that UV/VIS spectrophotometry are still popular because of the inherent simplicity, low cost, and reliability for determination of drugs in pharmaceutical preparations 2013 Article PeerReviewed Khatoon, Asma and Mohd. Setapar, Siti Hamidah and Ahmad, Akil and Lee, Nian Yian (2013) Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review. Der Pharma Chemica, 5 (3). pp. 79-85. ISSN 0975-413X https://www.derpharmachemica.com |
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QD Chemistry Khatoon, Asma Mohd. Setapar, Siti Hamidah Ahmad, Akil Lee, Nian Yian Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review |
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Amitrityline and its metabolite nortriptiline are tricyclic antidepressant drugs widely used for the treatment of several psychiatric disorders. Several methods have been published for the determination of these two antidepressant drugs in pharmaceuticals, biological materials and environmental samples. In this review some of analytical techniques such as ultraviolet/visible spectrophotometry, fluorimetry, capillary electrophoresis, and chromatographic methods (gaschromatography and high-performance liquid chromatography) were discussed. Although HPLC and capillary electrophoresis methods are extensively employed in spite of that UV/VIS spectrophotometry are still popular because of the inherent simplicity, low cost, and reliability for determination of drugs in pharmaceutical preparations |
format |
Article |
author |
Khatoon, Asma Mohd. Setapar, Siti Hamidah Ahmad, Akil Lee, Nian Yian |
author_facet |
Khatoon, Asma Mohd. Setapar, Siti Hamidah Ahmad, Akil Lee, Nian Yian |
author_sort |
Khatoon, Asma |
title |
Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review |
title_short |
Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review |
title_full |
Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review |
title_fullStr |
Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review |
title_full_unstemmed |
Analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review |
title_sort |
analytical methodologies for determination of amitriptyline and its metabolite nortriptyline: a review |
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2013 |
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http://eprints.utm.my/id/eprint/49410/ https://www.derpharmachemica.com |
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