Analytical method development and validation of anticancer agent, 5-fluorouracil, and its metabolites in biological matrices: an updated review

• Main Authors: Semail, Nadhiratul Farihin, Abdul Keyon, Aemi Syazwani, Saad, Bahruddin, Noordin, Siti Salmah, Nik Mohamed Kamal, Nik Nur Syazni, Mohamad Zain, Nur Nadhirah, Azizi, Juzaili, Kamaruzaman, Sazlinda, Yahaya, Noorfatimah
• Format: Article
• Published: Bellwether Publishing, Ltd. 2020
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/93280/; http://dx.doi.org/10.1080/10826076.2020.1781654

5-fluorouracil (5-FU) refers to a fluorinated pyrimidine analogue that has been widely used as an anticancer agent for colon, head, and neck cancers. Detection of 5-FU and its metabolites; 5-fluorouridine and 5-fluoro-2-deoxyuridine in biological samples allows optimization of pharmacotherapy and en...