Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)]
Reaction of organotin(IV) chloride(s) with 2-benzoylpyridine-N(4)- cyclohexylthiosemicarbazone, [HL] (1) yielded [MeSnCl 2(L)] (2), [BuSnCl 2(L)] (3), [Me 2SnCl(L)] (4), and [Ph 2SnCl(L)] (5). The ligand (1) and its organotin(IV) complexes have been characterized by CHN analyses, molar conductivity,...
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my.utm.338912018-11-30T06:41:18Z http://eprints.utm.my/id/eprint/33891/ Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)] Salam, M. A. Affan, M. A. Ahmad, Fasihuddin Arafath, Md. Azharul Mohamed Tahir, M. Ibrahim Shamsuddin, Mustaffa Q Science Reaction of organotin(IV) chloride(s) with 2-benzoylpyridine-N(4)- cyclohexylthiosemicarbazone, [HL] (1) yielded [MeSnCl 2(L)] (2), [BuSnCl 2(L)] (3), [Me 2SnCl(L)] (4), and [Ph 2SnCl(L)] (5). The ligand (1) and its organotin(IV) complexes have been characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, 1H, 13C, and 119Sn NMR spectral studies. The molecular structure of 5 was also determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and the central tin(IV) atom is six-coordinate in distorted octahedral geometry. The ligand (1) and complexes were screened for their invitro antibacterial activities. The cytotoxic activities of 1-5 were tested against A2780 and A2780/Cp8 cancer cell lines. The compounds have better antibacterial activities than the free ligand; 2-5 are more potent cytotoxic agents than 1, while the diphenyltin(IV) 5 is more active with IC 50 values of 0.05 and 0.54molL 1 against A2780 and A2780/Cp8 cell lines, respectively. Taylor and Francis Group 2012-07 Article PeerReviewed Salam, M. A. and Affan, M. A. and Ahmad, Fasihuddin and Arafath, Md. Azharul and Mohamed Tahir, M. Ibrahim and Shamsuddin, Mustaffa (2012) Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)]. Journal of Coordination Chemistry, 65 (18). pp. 3174-3187. ISSN 0095-8972 http://dx.doi.org/10.1080/00958972.2012.711823 DOI:10.1080/00958972.2012.711823 |
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Q Science Salam, M. A. Affan, M. A. Ahmad, Fasihuddin Arafath, Md. Azharul Mohamed Tahir, M. Ibrahim Shamsuddin, Mustaffa Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)] |
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Reaction of organotin(IV) chloride(s) with 2-benzoylpyridine-N(4)- cyclohexylthiosemicarbazone, [HL] (1) yielded [MeSnCl 2(L)] (2), [BuSnCl 2(L)] (3), [Me 2SnCl(L)] (4), and [Ph 2SnCl(L)] (5). The ligand (1) and its organotin(IV) complexes have been characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, 1H, 13C, and 119Sn NMR spectral studies. The molecular structure of 5 was also determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and the central tin(IV) atom is six-coordinate in distorted octahedral geometry. The ligand (1) and complexes were screened for their invitro antibacterial activities. The cytotoxic activities of 1-5 were tested against A2780 and A2780/Cp8 cancer cell lines. The compounds have better antibacterial activities than the free ligand; 2-5 are more potent cytotoxic agents than 1, while the diphenyltin(IV) 5 is more active with IC 50 values of 0.05 and 0.54molL 1 against A2780 and A2780/Cp8 cell lines, respectively. |
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Article |
author |
Salam, M. A. Affan, M. A. Ahmad, Fasihuddin Arafath, Md. Azharul Mohamed Tahir, M. Ibrahim Shamsuddin, Mustaffa |
author_facet |
Salam, M. A. Affan, M. A. Ahmad, Fasihuddin Arafath, Md. Azharul Mohamed Tahir, M. Ibrahim Shamsuddin, Mustaffa |
author_sort |
Salam, M. A. |
title |
Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)] |
title_short |
Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)] |
title_full |
Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)] |
title_fullStr |
Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)] |
title_full_unstemmed |
Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)] |
title_sort |
synthesis, characterization, antibacterial, and cytotoxic activities of organotin(iv) complexes derived from n (4)-cyclohexylthiosemicarbazone: x-ray crystal structure of [ph 2sncl(l)] |
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Taylor and Francis Group |
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2012 |
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http://eprints.utm.my/id/eprint/33891/ http://dx.doi.org/10.1080/00958972.2012.711823 |
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1643649461546647552 |
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13.160551 |