Synthesis, characterization, antibacterial, and cytotoxic activities of organotin(IV) complexes derived from N (4)-cyclohexylthiosemicarbazone: X-ray crystal structure of [Ph 2SnCl(L)]
Reaction of organotin(IV) chloride(s) with 2-benzoylpyridine-N(4)- cyclohexylthiosemicarbazone, [HL] (1) yielded [MeSnCl 2(L)] (2), [BuSnCl 2(L)] (3), [Me 2SnCl(L)] (4), and [Ph 2SnCl(L)] (5). The ligand (1) and its organotin(IV) complexes have been characterized by CHN analyses, molar conductivity,...
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Main Authors: | , , , , , |
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Format: | Article |
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Taylor and Francis Group
2012
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Online Access: | http://eprints.utm.my/id/eprint/33891/ http://dx.doi.org/10.1080/00958972.2012.711823 |
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Summary: | Reaction of organotin(IV) chloride(s) with 2-benzoylpyridine-N(4)- cyclohexylthiosemicarbazone, [HL] (1) yielded [MeSnCl 2(L)] (2), [BuSnCl 2(L)] (3), [Me 2SnCl(L)] (4), and [Ph 2SnCl(L)] (5). The ligand (1) and its organotin(IV) complexes have been characterized by CHN analyses, molar conductivity, UV-Vis, FT-IR, 1H, 13C, and 119Sn NMR spectral studies. The molecular structure of 5 was also determined by X-ray diffraction. There are two independent molecules in the asymmetric unit and the central tin(IV) atom is six-coordinate in distorted octahedral geometry. The ligand (1) and complexes were screened for their invitro antibacterial activities. The cytotoxic activities of 1-5 were tested against A2780 and A2780/Cp8 cancer cell lines. The compounds have better antibacterial activities than the free ligand; 2-5 are more potent cytotoxic agents than 1, while the diphenyltin(IV) 5 is more active with IC 50 values of 0.05 and 0.54molL 1 against A2780 and A2780/Cp8 cell lines, respectively. |
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