Cover Image

Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition

The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-? increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264....

Full description

Saved in:
Bibliographic Details
Main Authors: Abdelwahab, Siddig Ibrahim, Hassan, Loiy Elsir Ahmed, Mohd. Sirat, Hasnah, Yagi, Sakina M. Ahmed, Koko, Waleed Syaed, Mohan, Syam Morali, Taha, Manal Mohamed Elhassan, Ahmad, Syahida, Cheah, Shiau Chuen, Narrima, Putri, Rais, Mohd. Mustafa, Abdul Hadi, Abdul Hamid
Format: Article
Published: Elsevier 2011
Subjects:
Q Science
Online Access:http://eprints.utm.my/id/eprint/28785/
http://dx.doi.org/10.1016/j.fitote.2011.08.002
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The in vivo and in vitro mechanistic anti-inflammatory actions of cucurbitacin E (CE) (Citrullus lanatus var. citroides) were examined. The results showed that LPS/INF-? increased NO production in RAW264.7 macrophages, whereas L-NAME and CE curtailed it. CE did not reveal any cytotoxicity on RAW264.7 and WRL-68 cells. CE inhibited both COX enzymes with more selectivity toward COX-2. Intraperitoneal injection of CE significantly suppressed carrageenan-induced rat's paw edema. ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS.

Similar Items