Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.)

Single garlic has been known have various benefits because it contains many active compounds. The active compounds in garlic, like antioxidants are quickly degraded in the digestive tract. Various attempts have been made to maintain the antioxidants content in garlic through drug delivery systems. O...

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Main Authors: Sri Rahayu Lestari, Sri Rahayu Lestari, Nenes Prastita, Nenes Prastita, Siti lmroatul Maslikah, Siti lmroatul Maslikah, Sunaryono, Sunaryono, Abdul Gofur, Abdul Gofur, Fauziatul Fajaroh, Fauziatul Fajaroh, Yuslinda Annisa, Yuslinda Annisa, Nik Malek, Nik Ahmad Nizam
Format: Conference or Workshop Item
Published: 2023
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Online Access:http://eprints.utm.my/107909/
http://dx.doi.org/10.1063/5.0111654
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spelling my.utm.1079092024-10-16T06:45:27Z http://eprints.utm.my/107909/ Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.) Sri Rahayu Lestari, Sri Rahayu Lestari Nenes Prastita, Nenes Prastita Siti lmroatul Maslikah, Siti lmroatul Maslikah Sunaryono, Sunaryono Abdul Gofur, Abdul Gofur Fauziatul Fajaroh, Fauziatul Fajaroh Yuslinda Annisa, Yuslinda Annisa Nik Malek, Nik Ahmad Nizam Q Science (General) Single garlic has been known have various benefits because it contains many active compounds. The active compounds in garlic, like antioxidants are quickly degraded in the digestive tract. Various attempts have been made to maintain the antioxidants content in garlic through drug delivery systems. One of the drug delivery systems that can protect antioxidants is the Self Nanoemulsifying Drug Delivery System (SNEDDS). This study aims to characterize and test the antioxidant activity of SNEDDS single garlic extract (SGE). The methods used include single garlic extraction with ethanol solvent, SNEDDS formulation, SNEDDS preparation, SNEDDS response test, and physical tests. Characterization of SNEDDS size and morphology using Particle Size Analyzer (PSA) and Transmission Electron Microscopy (TEM). An antioxidant activity test was carried out using the DPPEI method. The results showed that the mean droplet size of SNEDDS-SGE was 23.10 ± 0.69 nm, the polydispersity index (PDI) was 0,46 ± 0,01 and the Zeta potential was -33.07±0.45 mV. The morphology of SNEDDS is a round droplet. The results of the antioxidant activity test showed that the percentage of antioxidant activity of SNEDDS-SGE was 56.74±1,04 which was higher than the percentage of antioxidant activity of SGE that was not prepared with SNEDDS 17.56 ±0.08. 2023 Conference or Workshop Item PeerReviewed Sri Rahayu Lestari, Sri Rahayu Lestari and Nenes Prastita, Nenes Prastita and Siti lmroatul Maslikah, Siti lmroatul Maslikah and Sunaryono, Sunaryono and Abdul Gofur, Abdul Gofur and Fauziatul Fajaroh, Fauziatul Fajaroh and Yuslinda Annisa, Yuslinda Annisa and Nik Malek, Nik Ahmad Nizam (2023) Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.). In: 4th International Conference on Life Science and Technology, ICoLiST 2023, 31 August 2021, Virtual, Online, Malang, Indonesia. http://dx.doi.org/10.1063/5.0111654
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Sri Rahayu Lestari, Sri Rahayu Lestari
Nenes Prastita, Nenes Prastita
Siti lmroatul Maslikah, Siti lmroatul Maslikah
Sunaryono, Sunaryono
Abdul Gofur, Abdul Gofur
Fauziatul Fajaroh, Fauziatul Fajaroh
Yuslinda Annisa, Yuslinda Annisa
Nik Malek, Nik Ahmad Nizam
Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.)
description Single garlic has been known have various benefits because it contains many active compounds. The active compounds in garlic, like antioxidants are quickly degraded in the digestive tract. Various attempts have been made to maintain the antioxidants content in garlic through drug delivery systems. One of the drug delivery systems that can protect antioxidants is the Self Nanoemulsifying Drug Delivery System (SNEDDS). This study aims to characterize and test the antioxidant activity of SNEDDS single garlic extract (SGE). The methods used include single garlic extraction with ethanol solvent, SNEDDS formulation, SNEDDS preparation, SNEDDS response test, and physical tests. Characterization of SNEDDS size and morphology using Particle Size Analyzer (PSA) and Transmission Electron Microscopy (TEM). An antioxidant activity test was carried out using the DPPEI method. The results showed that the mean droplet size of SNEDDS-SGE was 23.10 ± 0.69 nm, the polydispersity index (PDI) was 0,46 ± 0,01 and the Zeta potential was -33.07±0.45 mV. The morphology of SNEDDS is a round droplet. The results of the antioxidant activity test showed that the percentage of antioxidant activity of SNEDDS-SGE was 56.74±1,04 which was higher than the percentage of antioxidant activity of SGE that was not prepared with SNEDDS 17.56 ±0.08.
format Conference or Workshop Item
author Sri Rahayu Lestari, Sri Rahayu Lestari
Nenes Prastita, Nenes Prastita
Siti lmroatul Maslikah, Siti lmroatul Maslikah
Sunaryono, Sunaryono
Abdul Gofur, Abdul Gofur
Fauziatul Fajaroh, Fauziatul Fajaroh
Yuslinda Annisa, Yuslinda Annisa
Nik Malek, Nik Ahmad Nizam
author_facet Sri Rahayu Lestari, Sri Rahayu Lestari
Nenes Prastita, Nenes Prastita
Siti lmroatul Maslikah, Siti lmroatul Maslikah
Sunaryono, Sunaryono
Abdul Gofur, Abdul Gofur
Fauziatul Fajaroh, Fauziatul Fajaroh
Yuslinda Annisa, Yuslinda Annisa
Nik Malek, Nik Ahmad Nizam
author_sort Sri Rahayu Lestari, Sri Rahayu Lestari
title Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.)
title_short Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.)
title_full Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.)
title_fullStr Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.)
title_full_unstemmed Development of self nanoemulsifying drug delivery system (SNEDDS) to improve antioxidant activity of single garlic extract (Allium sativum L.)
title_sort development of self nanoemulsifying drug delivery system (snedds) to improve antioxidant activity of single garlic extract (allium sativum l.)
publishDate 2023
url http://eprints.utm.my/107909/
http://dx.doi.org/10.1063/5.0111654
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