Mathematical model of the generation of radiation-induced DNA double-strand breaks and misrepair cells by direct and indirect action

• Main Authors: Rashid, Hamizah, Mohd. Siam, Fuaada, Maan, Normah, Wan Abd. Rahman, Wan Nordiana, Nasir, Mohamad Hanis
• Format: Article
• Language: English
• Published: Penerbit UTM Press 2022
• Subjects: QA Mathematics
• Online Access: http://eprints.utm.my/id/eprint/102887/1/HamizahRashid2022_MathematicalModeloftheGenerationofRadiation.pdf; http://eprints.utm.my/id/eprint/102887/; http://dx.doi.org/10.11113/mjfas.v18n4.2406

Hydrated electron (eag-), hydroxyl radical (•OH), hydrogen radical (•H), ionized water, hydroperoxyl radical and hydrogen peroxide are examples of free radical products. Among these three free radicals, DNA damage dominantly caused by hydroxyl radical (•OH) because it is found to be highly reactive compared to others. This paper aimed to develop a model by using structured population dynamics approach to study the effects of ionizing radiation by direct and indirect actions. The effects of ionizing radiation are mathematically described in the model using Ordinary Differential Equations (ODEs). The simulation results are fitted to the Linear Quadratic (LQ) formulation to give the ratio for α/β. Next, the parameter estimation of the model is carried out using experimental data of human colon carcinoma cell by the aid of the MATLAB programming. The estimated parameter values can explain the biological meaning, which can support the result of the experimental design. The result showed that the sum-squared error (SSE) between simulation data and experimental data obtained is 0.0019 which indicates an excellent fit to the experimental data. Thus, the model developed is in line with the experimental result. The model can explain the dynamics process of the direct and indirect effect of ionizing radiation on the cell population.