Metabolomics approaches for early cancer diagnosis: A review
Cancer remains a major burden on global public health with high mortality rates worldwide. Current diagnosis can detect cancer in late stages when therapy options become limited. Early diagnosis is broadly recognized as the key to a better treatment to save lives. The metabolomics approach provides...
Saved in:
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Asian Journal of Agriculture and Biology
2022
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/101139/1/HeshamAliMetwally2022_MetabolomicsApproachesforEarlyCancerDiagnosis.pdf http://eprints.utm.my/id/eprint/101139/ http://dx.doi.org/10.35495/ajab.2020.12.566 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.101139 |
---|---|
record_format |
eprints |
spelling |
my.utm.1011392023-06-01T08:55:55Z http://eprints.utm.my/id/eprint/101139/ Metabolomics approaches for early cancer diagnosis: A review Boumehira, Ali Zineddine Akchiche, Yasmine Fatima Cherfi, Wissam Talhi, Oualid Djidjik, Reda Dailin, Daniel Joe Ho, Ting El Enshasy, Hesham Ali TP Chemical technology Cancer remains a major burden on global public health with high mortality rates worldwide. Current diagnosis can detect cancer in late stages when therapy options become limited. Early diagnosis is broadly recognized as the key to a better treatment to save lives. The metabolomics approach provides a better understanding of the different types of cancer. They offer promising and potential interventions in biomarkers discovery which eventually will be better suited for individualized medicine. It elucidates endpoint products for other omic processes while significantly improving the understanding of pathogenesis and mechanisms yet to be discovered. Metabolomics offers a less-invasive, cost-effective for predicting, screening, diagnosis, prognosis, and monitoring therapeutic responses of the disease. There are two methods to study the metabolism and metabolites: targeted and untargeted. The workflow of these approaches requires different analytical platforms, such as Nuclear Magnetic Resonance spectroscopy (NMR), Mass Spectrometry (MS), and different bioinformatic tools. This review provides a systematic summary of metabolomics methods in identifying metabolic biomarkers of cancers (colorectal, prostate, breast, bladder, pancreas, lung, and buccal cancers). In addition, the current review will try to shed light on DNA lesions as a potential metabolic biomarker for cancer. Asian Journal of Agriculture and Biology 2022 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/101139/1/HeshamAliMetwally2022_MetabolomicsApproachesforEarlyCancerDiagnosis.pdf Boumehira, Ali Zineddine and Akchiche, Yasmine Fatima and Cherfi, Wissam and Talhi, Oualid and Djidjik, Reda and Dailin, Daniel Joe and Ho, Ting and El Enshasy, Hesham Ali (2022) Metabolomics approaches for early cancer diagnosis: A review. Asian Journal of Agriculture and Biology, 2022 (4). pp. 1-22. ISSN 2307-8553 http://dx.doi.org/10.35495/ajab.2020.12.566 DOI : 10.35495/ajab.2020.12.566 |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
language |
English |
topic |
TP Chemical technology |
spellingShingle |
TP Chemical technology Boumehira, Ali Zineddine Akchiche, Yasmine Fatima Cherfi, Wissam Talhi, Oualid Djidjik, Reda Dailin, Daniel Joe Ho, Ting El Enshasy, Hesham Ali Metabolomics approaches for early cancer diagnosis: A review |
description |
Cancer remains a major burden on global public health with high mortality rates worldwide. Current diagnosis can detect cancer in late stages when therapy options become limited. Early diagnosis is broadly recognized as the key to a better treatment to save lives. The metabolomics approach provides a better understanding of the different types of cancer. They offer promising and potential interventions in biomarkers discovery which eventually will be better suited for individualized medicine. It elucidates endpoint products for other omic processes while significantly improving the understanding of pathogenesis and mechanisms yet to be discovered. Metabolomics offers a less-invasive, cost-effective for predicting, screening, diagnosis, prognosis, and monitoring therapeutic responses of the disease. There are two methods to study the metabolism and metabolites: targeted and untargeted. The workflow of these approaches requires different analytical platforms, such as Nuclear Magnetic Resonance spectroscopy (NMR), Mass Spectrometry (MS), and different bioinformatic tools. This review provides a systematic summary of metabolomics methods in identifying metabolic biomarkers of cancers (colorectal, prostate, breast, bladder, pancreas, lung, and buccal cancers). In addition, the current review will try to shed light on DNA lesions as a potential metabolic biomarker for cancer. |
format |
Article |
author |
Boumehira, Ali Zineddine Akchiche, Yasmine Fatima Cherfi, Wissam Talhi, Oualid Djidjik, Reda Dailin, Daniel Joe Ho, Ting El Enshasy, Hesham Ali |
author_facet |
Boumehira, Ali Zineddine Akchiche, Yasmine Fatima Cherfi, Wissam Talhi, Oualid Djidjik, Reda Dailin, Daniel Joe Ho, Ting El Enshasy, Hesham Ali |
author_sort |
Boumehira, Ali Zineddine |
title |
Metabolomics approaches for early cancer diagnosis: A review |
title_short |
Metabolomics approaches for early cancer diagnosis: A review |
title_full |
Metabolomics approaches for early cancer diagnosis: A review |
title_fullStr |
Metabolomics approaches for early cancer diagnosis: A review |
title_full_unstemmed |
Metabolomics approaches for early cancer diagnosis: A review |
title_sort |
metabolomics approaches for early cancer diagnosis: a review |
publisher |
Asian Journal of Agriculture and Biology |
publishDate |
2022 |
url |
http://eprints.utm.my/id/eprint/101139/1/HeshamAliMetwally2022_MetabolomicsApproachesforEarlyCancerDiagnosis.pdf http://eprints.utm.my/id/eprint/101139/ http://dx.doi.org/10.35495/ajab.2020.12.566 |
_version_ |
1768006614406660096 |
score |
13.154949 |