Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery

• Main Authors: Zainal Abidin, Hafzaliza Erny, Poh, Choon Ooi, Teck, Yaw Tiong, Marsi, Noraini, Ismardi, Abrar, Mohd Noor, Mimiwaty, Nik Zaini Fathi, Nik Amni Fathi, Abd Aziz, Norazreen, Sahari, Siti Kudnie, Sugandi, Gandi, Yunas, Jumril, Chang, Fu Dee, Majlis, Burhanuddin Yeop, Hamzah, Azrul Azlan
• Format: Article
• Language: English
• Published: Elsevier 2020
• Subjects: R855-855.5 Medical technology; T Technology (General)
• Online Access: http://eprints.uthm.edu.my/6294/1/AJ%202020%20%28258%29.pdf; http://eprints.uthm.edu.my/6294/; https://doi.org/10.1016/j.xphs.2020.04.019

In this study, we demonstrated the fabrication of the concave conic shape microneedle with the aid of COMSOL Multiphysics simulation. The stress and buckling of the microneedle structure were simulated by applying various loads ranging from 50 to 800 g perpendiculars to the tip in order to predict t...