Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery
In this study, we demonstrated the fabrication of the concave conic shape microneedle with the aid of COMSOL Multiphysics simulation. The stress and buckling of the microneedle structure were simulated by applying various loads ranging from 50 to 800 g perpendiculars to the tip in order to predict t...
Saved in:
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020
|
Subjects: | |
Online Access: | http://eprints.uthm.edu.my/6294/1/AJ%202020%20%28258%29.pdf http://eprints.uthm.edu.my/6294/ https://doi.org/10.1016/j.xphs.2020.04.019 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.uthm.eprints.6294 |
---|---|
record_format |
eprints |
spelling |
my.uthm.eprints.62942022-01-30T01:02:01Z http://eprints.uthm.edu.my/6294/ Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery Zainal Abidin, Hafzaliza Erny Poh, Choon Ooi Teck, Yaw Tiong Marsi, Noraini Ismardi, Abrar Mohd Noor, Mimiwaty Nik Zaini Fathi, Nik Amni Fathi Abd Aziz, Norazreen Sahari, Siti Kudnie Sugandi, Gandi Yunas, Jumril Chang, Fu Dee Majlis, Burhanuddin Yeop Hamzah, Azrul Azlan R855-855.5 Medical technology T Technology (General) In this study, we demonstrated the fabrication of the concave conic shape microneedle with the aid of COMSOL Multiphysics simulation. The stress and buckling of the microneedle structure were simulated by applying various loads ranging from 50 to 800 g perpendiculars to the tip in order to predict the occurrence of microneedles structure deformation. The simulation study indicated that the surface buckling deformation does not occur to the microneedle structure with the increment of the load. The microneedles with dimensions of height and diameter tip ranging from 60 to 100 μm and 1 to 4 μm, respectively had been fabricated via an etching process in a mixture of hydrofluoric acid, nitric acid, and acetic acid. Three optimized microneedles but different in the structures were fabricated via the acidic etching process. The reproducibility of three different microneedle structures was 15, 20, and 60%, respectively. Stress and buckling analyses of the fabricated microneedles were further carried out on the rat skin. The obtained experimental results show promising applications for the deep dermis, stratum corneum to epidermis layer penetration. Elsevier 2020 Article PeerReviewed text en http://eprints.uthm.edu.my/6294/1/AJ%202020%20%28258%29.pdf Zainal Abidin, Hafzaliza Erny and Poh, Choon Ooi and Teck, Yaw Tiong and Marsi, Noraini and Ismardi, Abrar and Mohd Noor, Mimiwaty and Nik Zaini Fathi, Nik Amni Fathi and Abd Aziz, Norazreen and Sahari, Siti Kudnie and Sugandi, Gandi and Yunas, Jumril and Chang, Fu Dee and Majlis, Burhanuddin Yeop and Hamzah, Azrul Azlan (2020) Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery. Journal of Pharmaceutical Sciences, 109 (8). pp. 2485-2492. ISSN 0022-3549 https://doi.org/10.1016/j.xphs.2020.04.019 |
institution |
Universiti Tun Hussein Onn Malaysia |
building |
UTHM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Tun Hussein Onn Malaysia |
content_source |
UTHM Institutional Repository |
url_provider |
http://eprints.uthm.edu.my/ |
language |
English |
topic |
R855-855.5 Medical technology T Technology (General) |
spellingShingle |
R855-855.5 Medical technology T Technology (General) Zainal Abidin, Hafzaliza Erny Poh, Choon Ooi Teck, Yaw Tiong Marsi, Noraini Ismardi, Abrar Mohd Noor, Mimiwaty Nik Zaini Fathi, Nik Amni Fathi Abd Aziz, Norazreen Sahari, Siti Kudnie Sugandi, Gandi Yunas, Jumril Chang, Fu Dee Majlis, Burhanuddin Yeop Hamzah, Azrul Azlan Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery |
description |
In this study, we demonstrated the fabrication of the concave conic shape microneedle with the aid of COMSOL Multiphysics simulation. The stress and buckling of the microneedle structure were simulated by applying various loads ranging from 50 to 800 g perpendiculars to the tip in order to predict the occurrence of microneedles structure deformation. The simulation study indicated that the surface buckling deformation does not occur to the microneedle structure with the increment of the load. The microneedles with dimensions of height and diameter tip ranging from 60 to 100 μm and 1 to 4 μm, respectively had been fabricated via an etching process in a mixture of hydrofluoric acid, nitric acid, and acetic acid. Three optimized microneedles but different in the structures were fabricated via the acidic etching process. The reproducibility of three different microneedle structures was 15, 20, and 60%, respectively. Stress and buckling analyses of the fabricated microneedles were further carried out on the rat skin. The obtained experimental results show promising applications for the deep dermis, stratum corneum to epidermis layer penetration. |
format |
Article |
author |
Zainal Abidin, Hafzaliza Erny Poh, Choon Ooi Teck, Yaw Tiong Marsi, Noraini Ismardi, Abrar Mohd Noor, Mimiwaty Nik Zaini Fathi, Nik Amni Fathi Abd Aziz, Norazreen Sahari, Siti Kudnie Sugandi, Gandi Yunas, Jumril Chang, Fu Dee Majlis, Burhanuddin Yeop Hamzah, Azrul Azlan |
author_facet |
Zainal Abidin, Hafzaliza Erny Poh, Choon Ooi Teck, Yaw Tiong Marsi, Noraini Ismardi, Abrar Mohd Noor, Mimiwaty Nik Zaini Fathi, Nik Amni Fathi Abd Aziz, Norazreen Sahari, Siti Kudnie Sugandi, Gandi Yunas, Jumril Chang, Fu Dee Majlis, Burhanuddin Yeop Hamzah, Azrul Azlan |
author_sort |
Zainal Abidin, Hafzaliza Erny |
title |
Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery |
title_short |
Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery |
title_full |
Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery |
title_fullStr |
Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery |
title_full_unstemmed |
Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery |
title_sort |
stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery |
publisher |
Elsevier |
publishDate |
2020 |
url |
http://eprints.uthm.edu.my/6294/1/AJ%202020%20%28258%29.pdf http://eprints.uthm.edu.my/6294/ https://doi.org/10.1016/j.xphs.2020.04.019 |
_version_ |
1738581474022522880 |
score |
13.18916 |