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Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity

The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methot...

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Main Author: Althiabat, Mohammad Gasem Mohammad
Format: Thesis
Language:English
Published: 2020
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf
http://eprints.usm.my/53495/
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spelling my.usm.eprints.53495 http://eprints.usm.my/53495/ Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity Althiabat, Mohammad Gasem Mohammad RS1-441 Pharmacy and materia medica The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα. 2020-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf Althiabat, Mohammad Gasem Mohammad (2020) Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity. Masters thesis, Universiti Sains Malaysia.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Althiabat, Mohammad Gasem Mohammad
Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
description The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα.
format Thesis
author Althiabat, Mohammad Gasem Mohammad
author_facet Althiabat, Mohammad Gasem Mohammad
author_sort Althiabat, Mohammad Gasem Mohammad
title Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_short Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_full Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_fullStr Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_full_unstemmed Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_sort rational drug design of new folic acid analogues with high binding affinity and anticancer activity
publishDate 2020
url http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf
http://eprints.usm.my/53495/
_version_ 1739828985911574528
score 13.211869

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