Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methot...
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| Format: | Thesis |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf http://eprints.usm.my/53495/ |
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