Screening For Small Molecule Inhibitors Of p27Kip1 Degradation

• Main Author: Ooi, Li Ching
• Format: Thesis
• Language: English
• Published: 2012
• Subjects: QH1 Natural history (General - Including nature conservation, geographical distribution)
• Online Access: http://eprints.usm.my/44880/1/OOI%20LI%20CHING.pdf; http://eprints.usm.my/44880/

In a majority of human cancers, the cyclin-dependent kinase (CDK) inhibitor p27Kip1 is commonly found to be deregulated due to proteolysis by the ubiquitin-proteasome pathway involving the SCFSkp2 E3 ligase. Although proteasome inhibitors act to stabilize p27Kip1, small molecules agents inhibiting t...