Screening For Small Molecule Inhibitors Of p27Kip1 Degradation
In a majority of human cancers, the cyclin-dependent kinase (CDK) inhibitor p27Kip1 is commonly found to be deregulated due to proteolysis by the ubiquitin-proteasome pathway involving the SCFSkp2 E3 ligase. Although proteasome inhibitors act to stabilize p27Kip1, small molecules agents inhibiting t...
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/44880/1/OOI%20LI%20CHING.pdf http://eprints.usm.my/44880/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|