Co-inheritance of compound heterozygous Hb constant spring and a single -α 3.7 gene deletion with heterozygous δβ thalassaemia: A diagnostic challenge

• Main Authors: R.Z., Azma,, A., Othman,, N., Azman,, H., Alauddin,, A., Ithnin,, N., Yusof,, N.F., Razak,, N.H., Sardi,, N.H., Hussin,
• Format: Article
• Language: en_US
• Published: 2015
• Subjects: α +thalassaemia ; δβ; Capillary electrophoresis; Hb constant spring; Molecular analysis; Thalassaemia
• Online Access: http://ddms.usim.edu.my/handle/123456789/8731

Haemoglobin Constant Spring (Hb CS) mutation and single gene deletions are common underlying genetic abnormalities for alpha thalassaemias. Co-inheritance of deletional and non-deletional alpha (α) thalassaemias may result in various thalassaemia syndromes. Concomitant co-inheritance with beta (β) a...