Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil
This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm oil on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two male Sprague-Dawley rats were divided into four groups: (i) control (basal diet), (...
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my.usim-84642015-12-29T08:39:39Z Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil Yusof, Kamisah, Kamsiah, Jaarin, Hj Mohd Saad, Qodriyah, Badlishah Sham, Nurul-Iman, Impaired Vasorelaxation Metabolic Syndrome Hypertension Atherosclerosis Consumption Parameters Increases Women This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm oil on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two male Sprague-Dawley rats were divided into four groups: (i) control (basal diet), (ii) VCO (1.42 mL/kg, oral), (iii) five-times-heated palm oil (15%) (5HPO), and (iv) five-times-heated palm oil (15%) and VCO(1.42 mL/kg, oral) (5HPO + VCO). Blood pressure was significantly increased in the group that was given the 5HPO diet compared to the control group. Blood pressure in the 5HPO + VCO group was significantly lower than the 5HPO group. Plasma nitric oxide (NO) level in the 5HPO group was significantly lower compared to the control group, whereas in the 5HPO + VCO group, the plasma NO level was significantly higher compared to the 5HPO group. Aortic rings from the 5HPO group exhibited attenuated relaxation in response to acetylcholine and sodium nitroprusside as well as increased vasoconstriction to phenylephrine compared to the control group. Aortic rings from the 5HPO + VCO group showed only attenuated vasoconstriction to phenylephrine compared to the 5HPO group. In conclusion, VCO prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil. 2015-06-19T06:56:01Z 2015-06-19T06:56:01Z 2013 Article 1741-427X http://ddms.usim.edu.my/handle/123456789/8464 http://www.hindawi.com/journals/ecam/2013/629329/ en_US Hindawi Publishing Corporation |
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Impaired Vasorelaxation Metabolic Syndrome Hypertension Atherosclerosis Consumption Parameters Increases Women |
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Impaired Vasorelaxation Metabolic Syndrome Hypertension Atherosclerosis Consumption Parameters Increases Women Yusof, Kamisah, Kamsiah, Jaarin, Hj Mohd Saad, Qodriyah, Badlishah Sham, Nurul-Iman, Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil |
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This study was performed to explore the effects of virgin coconut oil (VCO) in male rats that were fed with repeatedly heated palm oil on blood pressure, plasma nitric oxide level, and vascular reactivity. Thirty-two male Sprague-Dawley rats were divided into four groups: (i) control (basal diet), (ii) VCO (1.42 mL/kg, oral), (iii) five-times-heated palm oil (15%) (5HPO), and (iv) five-times-heated palm oil (15%) and VCO(1.42 mL/kg, oral) (5HPO + VCO). Blood pressure was significantly increased in the group that was given the 5HPO diet compared to the control group. Blood pressure in the 5HPO + VCO group was significantly lower than the 5HPO group. Plasma nitric oxide (NO) level in the 5HPO group was significantly lower compared to the control group, whereas in the 5HPO + VCO group, the plasma NO level was significantly higher compared to the 5HPO group. Aortic rings from the 5HPO group exhibited attenuated relaxation in response to acetylcholine and sodium nitroprusside as well as increased vasoconstriction to phenylephrine compared to the control group. Aortic rings from the 5HPO + VCO group showed only attenuated vasoconstriction to phenylephrine compared to the 5HPO group. In conclusion, VCO prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil. |
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Article |
author |
Yusof, Kamisah, Kamsiah, Jaarin, Hj Mohd Saad, Qodriyah, Badlishah Sham, Nurul-Iman, |
author_facet |
Yusof, Kamisah, Kamsiah, Jaarin, Hj Mohd Saad, Qodriyah, Badlishah Sham, Nurul-Iman, |
author_sort |
Yusof, Kamisah, |
title |
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil |
title_short |
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil |
title_full |
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil |
title_fullStr |
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil |
title_full_unstemmed |
Virgin Coconut Oil Prevents Blood Pressure Elevation and Improves Endothelial Functions in Rats Fed with Repeatedly Heated Palm Oil |
title_sort |
virgin coconut oil prevents blood pressure elevation and improves endothelial functions in rats fed with repeatedly heated palm oil |
publisher |
Hindawi Publishing Corporation |
publishDate |
2015 |
url |
http://ddms.usim.edu.my/handle/123456789/8464 http://www.hindawi.com/journals/ecam/2013/629329/ |
_version_ |
1645152421989580800 |
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13.214268 |