A case series of α-thalassemia intermedia due to compound heterozygosity for Hb Adana [HBA2: C179G>A (or HBA1); P.Gly60Asp] with other α-thalassemias in malay families

• Main Authors: Alauddin H., Jaapar N.-A., Azma R.Z., Ithnin A., Razak N.-F.A., Loh C.-K., Alias H., Abdul-Latiff Z., Othman A
• Format: Article
• Language: English
• Published: Informa Healthcare 2018
• Subjects: Codon 59 mutation; Hb Adana; Hb Constant Spring (Hb CS)
• Online Access: http://ddms.usim.edu.my:80/jspui/handle/123456789/15868

Hb Adana [HBA2: c179G>A (or HBA1); p.Gly60Asp] is a rare hemoglobin (Hb) variant due to a mutation at codon 59 of the α2- or α1-globin gene resulting in a glycine to aspartic acid substitution. Two siblings with a unique coinheritance of Hb Adana and Hb Constant Spring (Hb CS, α142, Term→Gln,...