Thalassemia intermedia in HbH-CS disease with compound heterozygosity for beta-thalassemia: challenges in hemoglobin analysis and clinical diagnosis

• Main Authors: Tan, J., Kok, J.L., Tan, K.L., Wee, Y.C., George, E.
• Format: Article
• Language: English
• Published: 2009
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3713/1/Thalassemia_intermedia_in_HbH-CS_disease_with_compound_heterozygosity.pdf; http://eprints.um.edu.my/3713/

Co-inheritance of alpha-thalassemia with homozygosity or compound heterozygosity for beta-thalassemia may ameliorate beta-thalassemia major. A wide range of clinical phenotypes is produced depending on the number of beta-thalassemia alleles (-alpha(alpha alpha--/alpha alpha, —/-alpha). The co-inheri...