Interleukin-27 disrupts the crosstalk of apoptotic activities between 4T1 breast cancer cells and M2 macrophages

• Main Authors: Mohd Yusof, Nurliyana, Mohamed Noor Fuadi, Natasha Nurafiqah, Hamid, Muhajir, Mohammed Alitheen, Noorjahan Banu, Mohd Hanafi, Nursyuhaida, Nik Abd Rahman, Nik Mohd Afizan
• Format: Article
• Language: English
• Published: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022
• Online Access: http://psasir.upm.edu.my/id/eprint/99343/1/2022112909315417_MJMHS_1425.pdf; http://psasir.upm.edu.my/id/eprint/99343/; https://medic.upm.edu.my/upload/dokumen/2022112909315417_MJMHS_1425.pdf

Introduction: Cytokine immunotherapy such as Interleukin-27 (IL-27) has been foreseen as a promising alternative anti-cancer treatment. Thus, this study aimed to investigate whether IL-27 gene therapy regulates crosstalk between breast cancer cells and macrophages in the sense of pro-apoptotic activ...