Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models

• Main Authors: Choo, Brandon Kar Meng, Kundap, Uday Praful, Mohd Faudzi, Siti Munirah, Abas, Faridah, Shaikh, Mohd Farooq, Samarut, Éric
• Format: Article
• Language: English
• Published: Elsevier 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/97598/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/97598/; https://www.sciencedirect.com/science/article/pii/S0753332221008180#:~:text=Complementary%20behavioral%20and%20brain%20seizure%20assays%20in%20zebrafish,screening%20pipeline%20identified%20two%20that%20have%20anti-seizure%20effects.

Seizures are the outward manifestation of abnormally excessive or synchronous brain activity. While seizures can be somewhat symptomatically managed with anti-epileptic drugs (AEDs), many patients are still refractory to the currently available AEDs. As a result, there is a need to identify new mole...