Mitragynine (Kratom)-induced cognitive impairments in mice resemble Δ9-THC and morphine effects: reversal by cannabinoid CB1 receptor antagonism

• Main Authors: Ismail, Nurul Iman, Ahmad, Nur Aimi Zawami, Mohd Yusof, Nurul Aiman, Talib, Ummi Nasrah, Norazit, Anwar, Kumar, Jaya, Mehat, Muhammad Zulfadli, Hassan, Zurina, Muller, Christian P., Muzaimi, Mustapha
• Format: Article
• Published: Frontiers Media 2021
• Online Access: http://psasir.upm.edu.my/id/eprint/94208/; https://www.frontiersin.org/articles/10.3389/fphar.2021.708055/full

Kratom is a widely abused plant-based drug preparation with a global interest in recent years, well beyond its native grounds in Southeast Asia. Mitragynine, its major psychoactive constituent is known to exhibit opioid-like behavioral effects with resultant neuroplasticity in the brain reward syste...